Bucha was born in Karachi. Her father was an airline Captain for Pakistan Airlines. Bucha has 2 sisters, Nimra Bucha and Bisma Bucha. She studied at the Convent of Jesus and Mary and completed her A Levels at The Lyceum School in Karachi. She graduated with a BA in Political Science from King's College London.
Bucha started off as a production development associate and became the producer for the first English Language Bulletin on GEO News. Other than producing it, Bucha frequently hosted the show. After the English bulletin, Bucha hosted and produced the channel’s first ever English Show News Day. She hosted and served as the executive director for the current affairs program Crisis Cell before switching over to the new program Laikin. Bucha covers topics such as Pakistani politics and foreign relations, South Asia and Middle East affairs and American involvement in the region.
In June 2012, Sana Bucha resigned from Geo News, allegedly over the hiring of Aamir Liaquat Hussain, who was also appointed as GEO's vice president; but later rejoined. In November 2012, Bucha resigned from Geo again, allegedly over Aamir Liaquat hosting a show about child activist Malala Yousufzai, and joined Dunya News.
In April 2013, she left Dunya News, tweeting, "This elections in Pak, every1 - channel and anchor - is up for sale. I refuse to put a price tag on myself. Left Dunya of my own free will."; although some sources alleged that she was fired.