Saint Joseph's College is located in Karachi, Sindh, Pakistan. It is a college for women, owned by the Roman Catholic Archdiocese of Karachi.
It was established by the religious order the Daughters of the Cross and is one of the most distinguished women's colleges in the country.  It was founded in 1948 and was one of the first colleges for women in Karachi.
The building was constructed by Brother Hilary Lardenoye OFM. Since 1951 it has been affiliated with the University of Karachi. It began as an Arts college with the Science faculty added in 1950. 
- Sr. Mary Albans (1948–1951)
- Sr. Mary Bernadette (1951–1961)
- Sr. Mary Emily (1961–1985 and 2005–2008)
- Mrs. Bilquis Iftikhar (1982 – 1983)
- Mrs. Munira Gulzar ( 1983 - 1993)
- Mrs. Kaniz J. Abedi (1993 - 1999)
- Mrs. Shahnaz Parveen (1999 - 2000)
- Dr. Tanveer Anjum (2000 - 2005)
- Mrs. Mary Caleb (2009 - 2010)
The college was nationalised in 1972 and denationalised in 2005, and returned to the Catholic Board of Education. On the 23 March 2009, the Government of Pakistan awarded the college principal Sister Mary Emily FC the Sitara-e-Imtiaz, which she received from the Governor of Sindh. This was in recognition of her services to education. 
The college offers students science, commerce and arts education at the Intermediate and baccalaureate levels. In 2011 St. Joseph's College started education of computer sciences at the intermediate level.
The new academic session begins in September each year. Students of the science group from both the Federal and Aga Khan Boards as well as Cambridge students seek admission here. Generally admissions for the science group will be closed at 75 per cent but could be varied depending on the other merits of the student. In 2008 about 125 Cambridge students, 23 students of the general group and 64 of Commerce applied for admission to the first-year. 
St.Josephs college focuses on co-curricular activities too. There are various clubs and societies which help students learn in a way they like.
The college provides a platform to the women of Karachi to understand the potential she possesses and the pivotal role that she can play as a responsible citizen.
The College held its graduation ceremony on November 18, 2012. 65 students were awarded BCom, BSc and BA degrees while nearly 450 intermediate students received their Higher Secondary School Certificates in pre-medical, pre-engineering, commerce and humanities.
- Sehba Musharraf, former First Lady of Pakistan
- Shahida Jamil, former Minister for Law & Parliamentary Affairs
- Fatima Sultan, Curator of South Asian American Art Festivals, USA
- Madiha Zeest Waheed, Lecturer, Institute of Business Management
- Sadia Rashid, Chairperson, Hamdard Laboratories Pakistan
- Seema Munaf, Professor, Institute of Clinical Psychology
- Lubna Farooq Malik, Director State Bank